Plymouth’s reward for knocking out Liverpool is a trip to Premier League champions Manchester City in the FA Cup fifth round, while holders Manchester United will play Fulham.
Plymouth, who are bottom of the Sky Bet Championship, earned a famous fourth-round win against Premier League leaders Liverpool at the weekend.
They now face a trip to City, after Pep Guardiola’s side overcame a first-half scare to beat Leyton Orient 2-1.
Man Utd have been drawn at home to Fulham. United beat Leicester 2-1 in controversial circumstances, with Harry Maguire appearing to be in an offside position as he headed in Friday’s stoppage-time winner at Old Trafford.
There was no VAR in operation during the fourth-round ties over the weekend, but the technology will come into play from the next round onwards.
Having won 2-0 at Everton on Saturday, Bournemouth will face more Premier League opposition with Wolves due at the Vitality Stadium.
Brighton, who came from behind to beat Chelsea 2-1, also have another tough assignment as they are away to Carabao Cup finalists Newcastle.
Cardiff, who needed penalties to get past Stoke, are away to Aston Villa – who hung on to knock out Tottenham 2-1 on Sunday.
Either Doncaster or Crystal Palace will be at home to Millwall, while the winners of Tuesday’s tie between Exeter and Nottingham Forest will be at home to Ipswich.
There will also be an all-Championship tie in the north-west with Preston due to host Burnley.
FA Cup fifth-round ties will be played around the first weekend of March, with the Football Association to confirm the full schedule in due course.
FA Cup fifth-round draw in full
Ties to be played around the first weekend of March
Preston vs Burnley
Aston Villa vs Cardiff City
Doncaster/Crystal Palace vs Millwall
Manchester United vs Fulham
Newcastle vs Brighton
Bournemouth vs Wolves
Manchester City vs Plymouth Argyle
Exeter City/Nottingham Forest vs Ipswich