2025 Men’s March Madness odds: Who is favored to make the Final Four?

UCLA edges No. 9 Michigan State 63-61 in front of Magic Johnson, Kareem Abdul-Jabbar

Before the men’s NCAA Tournament comes down to one team, it comes down to four. 

The Tournament began on March 18, and the Final Four is set to begin on April 5. 

Needless to say, bettors are looking ahead to see which teams will survive all the way to the semifinals. 

Check out the men’s Final Four odds at DraftKings Sportsbook as of March 24. 

To win East Region

Duke: -185 (bet $10 to win $15.41 total)
Alabama: +400 (bet $10 to win $50 total)
BYU: +900 (bet $10 to win $100 total)
Arizona: +750 (bet $10 to win $85 total)

To win Midwest Region

Houston: -130 (bet $10 to win $17.69 total)
Tennessee: +215 (bet $10 to win $31.50 total)
Kentucky: +700 (bet $10 to win $80 total)
Purdue: +750 (bet $10 to win $85 total)

To win South Region

Auburn: -135 (bet $10 to win $17.41 total)
Michigan State: +250 (bet $10 to win $35 total)
Michigan: +700 (bet $10 to win $80 total)
Ole Miss: +800 (bet $10 to win $90 total)

To win West Region

Florida: -130 (bet $10 to win $17.69 total)
Texas Tech: +320 (bet $10 to win $42 total)
Maryland: +450 (bet $10 to win $55 total)
Arkansas: +850 (bet $10 to win $95 total)

Entering the Sweet 16, the four favorites to make the Final Four are Duke, Houston, Auburn and Florida, the four No. 1 seeds in the Tournament.

Duke is also the favorite to win the national title, at +230. 

The last two Final Fours have been unique in nature in that all four teams haven’t been considered basketball powerhouses. In 2024, it was UConn, Purdue, Alabama and NC State. 

In 2023, it was UConn, San Diego State, Miami and Florida Atlantic. 

In both of those seasons, UConn emerged as the champion.

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